Takeshima N, Sozu T, Tajika A, Ogawa Y, Hayasaka Y, Furukawa TA. Metaprop: a stata command to perform meta-analysis of binomial data. Estimating the sample mean and standard deviation from the sample size, median, range and/or interquartile range. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Moher D, Liberati A, Tetzlaff J, Altman DG, Group P. Is 'functional end-to-end anastomosis' really functional? a review of the literature on stapled anastomosis using linear staplers. Kano M, Hanari N, Gunji H, Hayano K, Hayashi H, Matsubara H. Predictability of the postoperative course of Crohn's disease. Rutgeerts P, Geboes K, Vantrappen G, Beyls J, Kerremans R, Hiele M. Infliximab prevents Crohn's disease recurrence after ileal resection. Regueiro M, Schraut W, Baidoo L, Kip KE, Sepulveda AR, Pesci M, et al. Impact of the increasing use of immunosuppressants in Crohn's disease on the need for intestinal surgery. 2000 87(12):1697–701.Ĭosnes J, Nion-Larmurier I, Beaugerie L, Afchain P, Tiret E, Gendre JP. Risk factors for surgery and recurrence in 907 patients with primary ileocaecal Crohn's disease. A new antimesenteric functional end-to-end handsewn anastomosis: surgical prevention of anastomotic recurrence in Crohn's disease. Kono T, Ashida T, Ebisawa Y, Chisato N, Okamoto K, Katsuno H, et al. Thus, clinicians should consider the applicability of Kono-S anastomosis in respective institutions. Evidence from this meta-analysis favors the Kono-S anastomosis for CD patients, especially for ileocolic anastomosis. Complications were rare, with a 3% incidence of ileus (CI: 0.01–0.05), a 4% incidence of small bowel obstruction (CI: 0.01–0.10), a 1% incidence of an anastomotic leak incidence (CI: 0.00–0.03), and a 10% incidence of postoperative infection (CI: 0.03–0.20).

Endoscopic recurrence after sensitivity analysis was 5% (CI: 0.00–0.15). Surgical recurrence was pooled at an average of 0% (CI: 0.00–0.01) and a reduced mean Rutgeerts score of 1.375 (CI: 0.727–2.023) after Kono-S anastomosis.

We identified 676 patients who underwent surgery with a Kono-S anastomosis. Comparative data were analyzed using the Mantel–Haenszel model for dichotomous outcomes and the mean difference for continuous outcomes. Binominal data were analyzed after Freeman–Tukey double-arcsine transformation. We conducted this study to analyze the effectiveness of the Kono-S anastomosis, by searching Medline, Embase, CNKI, and google scholar. Since then, prevailing evidence of the favorable results of the Kono-S anastomosis has been published from around the world. The Kono-S anastomosis was introduced in 2011 as an alternative anastomosis in Crohn’s disease (CD) surgery.

Revman 5 meta-regression